The revelation comes as under-fire management at Betsi Cadwaladr University Health Board faces growing criticism over a possible reconfiguration of many of its services across the north of Wales.
The most significant pay rises between 2008-9 and 2009-10 include:
Chief Executive £150,000 to £190,000
Medical director £30,000 to £70,000
Director of nursing £95,000 to £120,000
Director of planning £100,000 to 120,000
Director of primary care £60,000 to £120,000
The top executives also had large rises in their pension pots with the Medical Director topping £1m and the chief executive's increasing in real terms by £110,000 in one year to £745,000.
Plaid Cymru's Llyr Huws Gruffydd, who tops the party's North Wales list, said:
"At a time when we're being told that we're all in it together, it cannot be right that top pay at our NHS board is rising to these levels.
"The pay rises for some of these executives is excessive when compared with the pay freeze public sector workers across north Wales are facing.
“This money should be prioritised for key frontline services not directed into the pockets of already highly paid executives. These individuals have a moral duty to play their part in these hard times.”
Plaid Cymru's Wrexham candidate for the Assembly Marc Jones said:
"Staff and patients will be astounded at these rises - it's very damaging for morale within the NHS. Plaid wants public money spent in the right places not raising the pay of top executives.
"Cuts imposed by the London government on the Welsh budget have seen public services in Wales having to tighten belts. It's important that senior managers realise that includes them as well."
• Full details of pay and pensions for senior managers on p54 of this report